BRAF Kinase Activation via Chromosomal Rearrangement in Radiation-Induced and Sporadic Thyroid Cancer
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چکیده
منابع مشابه
Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer
Recurrent translocations are well known hallmarks of many human solid tumors and hematological disorders, where patient- and breakpoint-specific information may facilitate prognostication and individualized therapy. In thyroid carcinomas, the proto-oncogenes RET and NTRK1 are often found to be activated through chromosomal rearrangements. However, many sporadic tumors and papillary thyroid carc...
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Genes crucial for cancer development can be mutated via various mechanisms, which may reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding for effectors along the MAPK pathway are central for transformation. BRAF point mutation is most common in sporadic tumors. By contrast, radiation-induced tumors are associated with paracentric inversions activating t...
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Background: The increasing prevalence of thyroid cancer among the survivors of atomic bomb attacks in Japan, nuclear fallout in the Marshall Islands, and Chernobyl nuclear power plant accident indicate a strong relationship between nuclear radiation and the occurrence of thyroid cancer. Materials and Methods: Systematic researches were conducted in the medical database of the American National ...
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Background: Radiotherapy is regarded as a standard treatment modality in breast cancer (BC). Radiation causes cellular damage both in cancer and normal cells by inducing DNA-damage and chromosomal aberrations (CA). Different agents were used for ameliorating effects of radiation, mainly antioxidants such as melatonin. Melatonin shows oncostatic properties on human BC. The aim of this study was ...
متن کاملReply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced t...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2005
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.4.4.1631